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About this conversation
Single-cell profiling identifies ten interstitial macrophage subsets and clarifies how distinct chemokine programs coordinate inflammatory responses.
We thank Dr. Xin Li for sharing the research, the thinking behind the discovery, and the challenges and decisions that shaped the work with the Biolà community.
PAPERS & REFERENCES
Nature ImmunologyEVENT MATERIALS
On September 1 at 9:00 AM Beijing Time, Biolà hosted the 3rd issue of the Bioneer First-Author Forum, featuring Dr. Xin Li from the Geisel School of Medicine at Dartmouth. Dr. Li presented the study “Coordinated Chemokine Expression Defines Macrophage Subsets Across Tissues,” published in Nature Immunology in 2024.
The study investigated the heterogeneity and functional roles of interstitial macrophages (IMs), an understudied macrophage population in the lung. By identifying ten IM subsets based on chemokine and other distinguishing gene-expression patterns, the authors characterized their dynamic state changes following stimulation and identified key regulons associated with distinct IM phenotypes. In inflammatory models, the loss of CD206^hi^ IMs markedly reduced leukocyte recruitment and inducible bronchus-associated lymphoid tissue (iBALT) formation, revealing an important role for specific IM subsets in coordinating inflammatory responses.
We sincerely thank Dr. Xin Li for sharing the findings and research process behind this work with the Biolà community, and for the thoughtful discussion with our members.
Citation: Li, X., Mara, A. B., Musial, S. C., et al. (2024). Coordinated chemokine expression defines macrophage subsets across tissues. Nature Immunology, 25, 1110–1122. https://doi.org/10.1038/s41590-024-01826-9